By using the technique of turbulent large eddy simulation (LES) and finite element method (FEM) of computational fluid dynamics (CFD), the three dimensional flow fields in vector flow clean-room under empty state and static state condition were predicted. The partly expanded Taylor-Galerkin discretization scheme cooperated with implicit stream-upwind diffusion effect was used to deduce the finite element formulation of basic equations through Gauss filtering. The subgrid model of vortex viscosity was adopted in the numerical simulation. As the results of the calculation agree well with the available experimental data, the method of LES was proved to be more accurate to provide the size and location of large eddies in clean-rooms than the standard k- ε two-equation model.