Enthalpy exchangers have been widely used for achieving comfortable air-conditioning with lower energy consumption. Desiccant materials such as silica gel and molecular sieves are used so as to give it a latent heat exchanging function. However, this important function has become the cause of cross-contamination because the substances with an offensive odor are also adsorbed in the desiccant. In this paper, cross-contamination of an enthalpy wheel consisting of ion-exchange resin particles as a desiccant material is examined and the results are compared with those of a commercialized 3A zeolite wheel. It is found that the Ion-exchange resin type wheel showed smaller cross-contamination ratio than that of the other for all the contaminants tested in this study, ammonia, carbon dioxide, formaldehyde and propane.